Best Mushrooms for Anxiety – Top 5 Medicinal Mushrooms for Stress Relief (backed by science)

 

The age of stressed out
The age of overwhelm

The Age of Overwhelm

Take a deep breath.
Now ask yourself—when was the last time I truly felt calm?

For many of us, stress has become the default setting. We wake up to alarms, scroll through a flood of bad news, juggle endless responsibilities, and crash into bed wondering why we still feel wired and exhausted at the same time. Anxiety isn’t just a personal issue—it’s become a cultural condition. This especially rings true for a person like me, a business owner, a single mom to an 11 year old, with multiple pets, a house to take care of every day, the garden to tend to, and meals to cook. The list goes on, and I know you relate to this too. 

“Nature offers us tools—not to escape stress, but to respond to it differently.”

In a world where hustle is glorified and downtime feels like a guilty pleasure, it’s no surprise that our nervous systems are begging for support. According to the American Psychological Association, more than three-quarters of adults report experiencing physical symptoms of stress. That tension in your shoulders? The brain fog? The racing heart? It’s not just in your head—it’s in your biology.

But here’s the good news: we can take our power back. Nature offers us tools—not to escape stress, but to respond to it differently. By cultivating daily practices that nurture our nervous systems and bodies, we can begin to shift the tide. And among the most powerful allies in this journey are mushrooms.

Mushroom into a Better Future
Mushroom into a Better Future

In this article, we’ll explore not only the best mushrooms for easing anxiety and building resilience, but also how to pair them with other holistic practices—like journaling, intention-setting, and time in nature—to create a truly nourishing routine for modern life.

Why Are We All So Stressed Out?

We weren’t designed to live like this.

Our bodies evolved in a world of rhythmic cycles—sunrise and sunset, movement and rest, seasons of growth and retreat. Today, we live in a 24/7 society that rarely pauses. Emails ping at midnight. Social media scrolls endlessly. Work follows us home. The result? Our nervous systems are stuck in perpetual overdrive.

The stress response—also known as fight-or-flight—was meant to be temporary. It kicks in when we’re in danger, pumping adrenaline and cortisol through the body so we can respond. But modern life keeps flipping that switch with no off button. From traffic to financial strain, from doomscrolling to decision fatigue, we’re constantly reacting instead of regulating.

And when stress becomes chronic, it starts to change us. It affects everything from our sleep to our digestion, our mood to our memory. We feel wired but tired, overwhelmed yet unable to focus. Our bodies hold the tension, and our minds spin with worry.

Add to that a culture that often shames rest and glorifies being “busy,” and it’s easy to see why anxiety and burnout are at an all-time high. Many of us are functioning in survival mode, disconnected from the simple practices that could help us feel grounded, nourished, and whole.

But here’s the truth: stress isn’t the enemy. It’s the chronic, unmanaged kind that causes harm. When we learn how to listen to our bodies and support our nervous systems intentionally, stress becomes something we can work with—not something that runs the show.

Man sitting under a tree
Man relaxing under tree

That’s where daily practices and plant allies come in. Before we dive into the top mushrooms for anxiety, let’s look at a few foundational habits that can help you build resilience from the inside out.

Stress Relief is a Practice, Not a Quick Fix

In a culture obsessed with instant results, it’s tempting to look for a magic bullet—a supplement, a smoothie, a meditation app that will finally make the stress go away. But real relief isn’t found in a single product or practice. It’s built over time, through intentional daily choices that support your nervous system and gently rewire your response to stress.

Think of it like tending a garden. You don’t water your plants once and expect them to thrive forever. You check in daily. You notice what needs nourishment. You pull weeds, make space, and let sunlight in. Your mind and body deserve that same kind of care.

The thing is, you don’t need a full lifestyle overhaul. Tiny shifts, practiced consistently, can create massive change. Here are some tools I  love—simple, science-supported habits that, when paired with medicinal mushrooms, can help you build a calm, resilient foundation:

1. Journaling

Writing down your thoughts and emotions can help process anxious loops and bring clarity to the chaos. Even five minutes of “brain dumping” can shift your state.

2. Meditation & Breathwork

These practices activate the parasympathetic nervous system—the body’s natural “rest and digest” mode. They’re proven to reduce cortisol and increase emotional regulation.

3. Time in Nature

A walk in the woods lowers blood pressure, eases mental fatigue, and reconnects you with rhythms beyond the algorithm. This is called forest bathing, and it’s legitimate medicine.

4. Daily Rituals & Intention Setting

Lighting a candle. Drinking tea mindfully. Saying out loud, “Today I choose ease.” Ritual creates rhythm. And rhythm helps soothe the nervous system.

5. Prioritizing Sleep

Lack of sleep doesn’t just make you tired—it amplifies stress, reduces your ability to cope, and worsens anxiety. Mushrooms like Reishi can help here.

Stress relief is a practice of remembering who you are beneath the overwhelm—and creating space each day to return to that place.

Into The Woods I go
Into The Woods I Go, To lose my mind, and find my soul!

In the next section, we’ll explore how medicinal mushrooms fit into this toolkit—not as a cure-all, but as wise allies that help your body remember how to find balance.

How Mushrooms Help with Anxiety and Stress

When it comes to managing stress naturally, few allies are as fascinating—or as effective—as medicinal mushrooms.

These powerful fungi have been used for centuries in traditional medicine systems to promote balance, longevity, and resilience. What makes them so special? They’re adaptogens—natural substances that help the body adapt to physical, emotional, and environmental stress. Instead of forcing your body into a state (like caffeine or sedatives might), adaptogens work with your body to restore equilibrium.

Mushrooms as Nervous System Nourishers

Stress and anxiety are deeply rooted in the nervous system. When we’re overwhelmed, our bodies activate the sympathetic (fight-or-flight) response. Medicinal mushrooms like Reishi and Lion’s Mane help bring the parasympathetic (rest-and-digest) system back online—calming the body, sharpening the mind, and creating a greater sense of inner safety.

Some mushrooms are neuroprotective, helping regenerate and support the brain’s structure and function. Others help regulate cortisol (the primary stress hormone), soothe inflammation, or support the gut microbiome—which has a direct impact on mood via the gut-brain axis.

Science Meets Tradition

Modern research is catching up with ancient wisdom. Studies show that medicinal mushrooms can:

  • Reduce symptoms of anxiety and depression
  • Improve sleep quality and energy regulation
  • Support adrenal health and resilience under stress
  • Promote neurogenesis (growth of new brain cells)
  • Enhance mood and cognitive clarity

And unlike some fast-acting substances, mushrooms work gently and steadily—encouraging long-term balance rather than short-term sedation.

Mushrooms Are Not a Solo Act

While these fungi are powerful, they work best when paired with lifestyle practices like the ones we explored earlier. Think of mushrooms as the foundation—a steady, daily support that reinforces the work you’re doing with your breath, your rest, your rituals, and your healing intentions.

Nature Meditation
Relaxed man sitting on log in forest meditating in nature.

Up next, we’ll break down the top five medicinal mushrooms that science (and centuries of tradition) point to as the most effective for reducing anxiety and building stress resilience.

The Top 5 Mushrooms for Stress Relief (with Benefits & Science)

Not all mushrooms are created equal when it comes to managing stress and anxiety. Some specialize in calming the nervous system, others nourish the brain, and a few help regulate energy and immunity—so your body can handle stress more gracefully over time.

Here are our top five favorite medicinal mushrooms for stress relief, backed by research and rooted in centuries of traditional wisdom:

1. Reishi (Ganoderma spp.)

The Queen of Calm

  • What it helps with: Sleep support, anxiety, tension, adrenal fatigue
  • How it works: Reishi is one of the most revered adaptogens for its deeply calming effects on the body and mind. It helps regulate the hypothalamic-pituitary-adrenal (HPA) axis, which is responsible for your stress response. It also supports GABA pathways—your brain’s natural brakes.
  • Scientific backing: Studies have shown Reishi may reduce symptoms of anxiety, support better sleep, and lower cortisol levels over time. 
  • Best time to take: In the evening or before bed
Golden Reishi Mushroom
Golden Reishi Mushroom

 2. Lion’s Mane (Hericium erinaceus)

The Brain Booster

  • What it helps with: Brain fog, anxiety, mood swings, focus
  • How it works: Lion’s Mane stimulates the production of nerve growth factor (NGF), a protein that supports the growth and repair of brain cells. It’s been shown to ease mild symptoms of depression and anxiety by supporting cognitive function and emotional regulation.
  • Scientific backing: Clinical studies suggest Lion’s Mane can improve cognitive performance and reduce anxiety and irritability, especially in women undergoing menopause or people with mild cognitive impairment. [2]
  • Best time to take: Morning or early afternoon
Lion's Mane Mushroom
Lion’s Mane Mushroom

3. Cordyceps (Cordyceps militaris/sinensis)

The Adaptogen Energizer

  • What it helps with: Fatigue, burnout, low motivation
  • How it works: Cordyceps helps improve the body’s oxygen use and energy production at the cellular level. It supports the adrenal glands and balances stress-induced fatigue without overstimulation (unlike caffeine).
  • Scientific backing: Research shows Cordyceps can improve energy, stamina, and stress resilience—especially in athletes and people under high physical or emotional demand. [3]
  • Best time to take: Morning or pre-workout
Cordyceps Mushroom
Cordyceps Mushroom

 4. Chaga (Inonotus obliquus)

The Antioxidant Defender

  • What it helps with: Inflammation, oxidative stress, gut-brain imbalance
  • How it works: Chaga is packed with antioxidants that help lower inflammation—a key contributor to chronic stress. It also supports the immune system and gut health, which are both tightly linked to emotional well-being.
  • Scientific backing: Chaga extracts have demonstrated neuroprotective and anti-inflammatory effects in animal studies, with promising results for supporting mood and resilience. 
  • Best time to take: Any time of day
Chaga Mushroom
Chaga Mushroom

5. Turkey Tail (Trametes versicolor)

The Gut-Immune Connector

  • What it helps with: Immune stress, gut health, emotional resilience
  • How it works: Turkey Tail supports the microbiome, which plays a huge role in mood and stress regulation. It’s rich in prebiotic fibers and compounds like PSP and PSK, which also modulate immune response—helping reduce background “body stress.”
  • Scientific backing: Research highlights its immune-supportive effects and potential mood benefits via microbiota-gut-brain axis interactions. 
  • Best time to take: With meals
Turkey Tail Mushroom
Turkey Tail Mushroom

 Bonus Mention: Poria (Poria cocos)
A lesser-known but powerful mushroom used in Traditional Chinese Medicine for calming the spirit, easing worry, and promoting restful sleep—especially when anxiety is rooted in digestion or fluid imbalance.

Poria Mushroom
Poria Mushroom

Up next, we’ll walk you through how to use these mushrooms in real life—whether you’re sipping tea, taking a tincture, or blending a daily extract into your wellness routine.

How to Use These Mushrooms

Once you know which mushrooms can support your stress response, the next question is: How do I actually use them? The beauty of medicinal mushrooms is their versatility—they can be taken in many forms to fit your lifestyle and preferences.

Extracts vs. Powders vs. Teas

Each preparation method has its own benefits. Here’s a quick breakdown:

  • Dual Extracts (like Mycomatrix):
    These are alcohol + hot water extracts, which means you’re getting both water-soluble compounds (like beta-glucans) and alcohol-soluble compounds (like triterpenes). Dual extracts are highly bioavailable and ideal for stress support and long-term use.
Mycomatrix Adaptogenic Extracts
Mycomatrix Adaptogenic Extracts
  • Powders:
    Great for blending into smoothies, coffee, or cooking. However, they’re often less potent unless they’ve been pre-extracted. Look for “extract powder” on the label.
Extracted Mushroom Powder
Extracted Mushroom Powder
  • Teas & Decoctions:
    A beautiful and traditional way to connect with mushrooms, especially with whole dried fruiting bodies like Reishi or Chaga. Best when you have time to slow down and steep.
Tea and Extracts
Woman holding a cup of tea

Pro tip: Not all mushrooms are digestible in raw or unextracted form—especially tough ones like Reishi and Chaga. Extracts make them easier to absorb and more effective.

How Often Should You Take Them?

Consistency is key when it comes to adaptogens. These mushrooms don’t work like a sedative or stimulant—they build resilience gradually.

  • Daily use is recommended for best results.
  • You can cycle certain mushrooms (like Cordyceps) or pair them to match your needs (Lion’s Mane in the morning, Reishi at night).
  • Pay attention to how you feel—adjust timing and combinations based on your body’s response.
Mushrooms, On your Schedule
Mushrooms, On Your Schedule – Mycomatrix Subscriptions – Save Today!

Why Mushroom Mountain’s Extracts?

At Mushroom Mountain, we craft all of our Mycomatrix extracts using full-spectrum, fruiting body mushrooms. Our extraction process ensures you’re getting the maximum benefit from each species—no filler, no fluff, just pure mushroom power. Visit our website to find out more. You may also call us, and we can guide you through the discovery process of what extracts could be beneficial for you. 

Whether you’re navigating anxiety, recovering from burnout, or just wanting to feel more steady in your day-to-day life, our extracts are designed to support your real-life rhythm—without adding more complexity to your wellness routine.

Mycomatrix Adaptogenic Mushroom Extracts
Mycomatrix Adaptogenic Mushroom Extracts

In the next (and final) section, we’ll share ideas for creating your own daily stress relief ritual—with medicinal mushrooms as a foundational part of your toolkit.

Create Your Daily Stress Relief Ritual

Now that you’ve met your mushroom allies and understand how they work, it’s time to weave them into your life in a way that feels natural, nourishing, and doable. This isn’t about perfection—it’s about building a rhythm of care that supports you, day by day.

Morning: Set the Tone

Start your day with clarity and intention.

  • Mushroom pairing: Lion’s Mane + Cordyceps
  • Ritual idea: Add extracts to your coffee, tea, or smoothie. Take a few deep breaths. Write down three intentions or gratitudes. Ask yourself: What would support me most today?

This combo brings mental focus, energy, and resilience for whatever the day throws your way—without the crash.

Morning Stretching
Morning stretching sets the tone for your movement throughout the day

Midday: Ground and Reset

Instead of powering through stress, take a pause to recalibrate.

  • Mushroom pairing: Chaga or Turkey Tail
  • Ritual idea: Step outside. Sip a warm drink with your mushroom extract. Close your eyes. Breathe into your belly. Release tension from your shoulders and jaw.

Even a five-minute reset can make a huge difference in how you move through the rest of your day.

Midday Reset
Take frequent breaks to reset your brain

Evening: Unwind and Restore

Let your body know it’s safe to rest.

  • Mushroom pairing: Reishi
  • Ritual idea: Create a wind-down window. Turn off screens. Take Reishi extract in a warm herbal tea or elixir. Light a candle. Journal or stretch. Let stillness be enough.

This simple evening ritual helps signal to your nervous system that it’s okay to relax. Over time, Reishi can support deeper sleep and emotional resilience.

Nightly bed routines set the tone for the next day.

You Deserve to Feel Calm, Clear, and Resilient

The world may not slow down—but you can. With the support of medicinal mushrooms, intentional habits, and compassion for your own process, you can begin to build a life that feels grounded and sustainable.

Start small. Start where you are. Let the mushrooms meet you there.

Relaxation

Ready to Begin?

🍄‍🟫 Explore our Mycomatrix Stress Support Collection and start building your own daily ritual.
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Experience Harmony with Nature
Experience Harmony with Nature

Supporting Research

Reishi – Calming & Cortisol Support

Lion’s Mane – Brain Function & Stress Reduction

  • In a randomized, placebo-controlled 28‑day study, healthy adults taking 1.8 g Lion’s Mane daily showed faster cognitive performance (Stroop task) and a trend toward reduced subjective stressfrontiersin.org+8pmc.ncbi.nlm.nih.gov+8health.com+8.
  • Another trial in menopausal women (500 mg, 4x/day for four weeks) showed significant reductions in anxiety and depression symptoms .

Cordyceps – Energy, Fatigue, & Stress Resilience

  • Adaptogenic properties of Cordyceps include balancing cortisol—raising it during stress and lowering it otherwise—to buffer fatigue and support endurance, as seen in long-distance cyclists medicalnewstoday.com+13procerahealth.com+13healthline.com+13.
  • Lab and animal studies also highlight its potential for improving inflammation, metabolism, and physical staminaverywellhealth.com.

Chaga – Antioxidant & Neuroprotective Effects

  • In vitro studies show Chaga extracts possess strong antioxidant and neuroprotective activity, protecting against oxidative damage thought to play a role in stress and cognitive decline .
  • Recent clinical investigations suggest benefits in modulating neuroinflammationthescottishsun.co.uk+2pmc.ncbi.nlm.nih.gov+2eversiowellness.com+2.

Turkey Tail – Gut–Brain & Immune Support

Adaptogens & General Support

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